Different types of breast cancer are classified by whether or not the cancer cells have certain proteins called receptors. Cancer cells may have receptors for 2 types of hormones (estrogen or progesterone) or another receptor called HER2. If cancer cells have (or are positive for) these certain types of receptors, they can be treated with therapies that target those receptors or that cause the body to make fewer hormones.
But mTNBC cells are negative for estrogen receptors, progesterone receptors, and HER2, which means they tested negative for those 3 receptors, hence the name triple-negative breast cancer. Without these receptors, treatment for mTNBC is more limited than other types of breast cancer and may require a different approach.
Unlike some other therapies, TRODELVY does not need cancer cells to have estrogen receptors, progesterone receptors, or HER2 in order to work, which is why it is an option for people with mTNBC. Rather, TRODELVY is designed to seek out a different protein that may be present on breast cancer cells, including those found in mTNBC. See how TRODELVY is thought to work.
TRODELVY® (sacituzumab govitecan-hziy) is a prescription medicine used to treat adults with triple-negative breast cancer (negative for estrogen and progesterone hormone receptors and HER2) that has spread to other parts of the body (metastatic) or cannot be removed by surgery, and who have received two or more prior treatments, including at least one treatment for metastatic disease.
Here are some additional resources that may be helpful to patients, families, and care partners dealing with breast cancer. The following resources are not controlled or owned by Gilead, and Gilead is not responsible for their content.
Breastcancer.org: A complete resource for patients with breast cancer.
Living Beyond Breast Cancer®: Information, community, and support for people whose lives have been impacted by breast cancer.
METAvivor: Dedicated to increasing awareness of advanced breast cancer and equity in research and patient support.
Share Cancer Support: A supportive community of women affected by breast or ovarian cancer.
Sharsheret®: A Jewish breast cancer organization that helps women and their families face breast cancer.
Sisters Network® Inc: Committed to increasing local and national attention to the devastating impact that breast cancer has in the African American community.
Triple Negative Breast Cancer Foundation®: Dedicated to raising awareness of triple-negative breast cancer.
Young Survival Coalition®: Dedicated to the critical issues unique to young women who are diagnosed with breast cancer.